A branch of Kwik Fit in Manor Park, Newham, is ablaze, with smoke and flames leaping into the night sky.
London Fire brigade says that eight fire engines and around 60 firefighters are tackling the blaze at the tyre workshop.
Most of the large industrial unit on High Street North has been completely consumed by flames.
The cause of the blaze is unknown.
It isn’t yet clear if there have been any injuries.
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