Cops were called to Hackney just before 2.45pm on Friday to reports of a man suffering stab injuries on Frampton Park Road.
Police were then told of another man who had been stabbed in nearby Wilton Way.
Scotland Yard said one man has been detained by officers and enquiries continue.
The London Ambulance Service are on scene but the condition of the victims is not yet known.
The double attack follows a slew of stabbings in London and across the UK.
Yesterday it emerged that knife crime in England and Wales has surged to its highest level on record.
On Wednesday night an 18-year-old lad was killed in the Harborne area of Birmingham.
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