Georgina will be one of the managers at the centre which will be part of the Insparya Group which Ronaldo co-founded with fellow Portuguese Paulo Ramos.
Ronaldo is well known for his perfectionism and the lengths that he is prepared to go in order to keep his body in peak form.
It is a big project with 150 people set to be employed with 18 hair transplants a day taking place.
The Juventus superstar is believed to be ready to invest 26 million euros over the next three or four years.
A statement from Ronaldo read: “In addition to football, I am passionate about health, technology and research, they are areas which I wanted to invest in.
“I wanted the first clinic of the international expansion to be situated in Madrid, a city I lived in for many years.”
Hair transplants at the six-storey clinic will reportedly start from 4,000 euros and Ronaldo will be at the opening on March 18.
Clearly the idea is to make the centre a the place to go for hair transplants, with currently many people travelling to Turkey.
Spokeswoman Carla Palanca said: “The clinic will offer packages for foreign clients, offering a stay in the hotel, airport transfers and transport to and from the clinic during the treatment so that clients will be able to do the treatment here instead of Turkey.”
Ronaldo’s business partner Paulo Ramos said: “We have the knowledge, but to open clinics outside Portugal we need a reputation.
“He will give us that push, we want to open the next centre in 2019 or 2020.”
Ronaldo played for Real Madrid from 2009 until last summer and has gone down as one of their best ever players, on a par with Alfredo Di Stefano.
He was instrumental in Los Blancos winning four Champions Leagues during his time at the Bernabeu.