The politician, 55, is spoofed in the channel’s new series Year Of The Rabbit with an outspoken character called Neil Fromage.
He is shot in the head while making a speech about the dangers of immigration.
Weeks after comedian Jo Brand joked about throwing battery acid over Mr Farage in a BBC radio show, Channel 4 now find themselves in a similar row.
Mr Farage blasted the stunt and warned it could incite violence.
He told the Daily Star Sunday: “This scene is totally sick and frankly irresponsible.”
The former Ukip leader also slammed Channel 4 executives for not censoring the scene.
“This scene is totally sick and frankly irresponsible”
Brexit party leader Nigel Farage
He said: “I think with Channel 4 we have reached a point where they are so partisan politically in everything they do that they now consistently go beyond what’s acceptable.”
The episode has been available to Sky customers through their ondemand service and is due to air on Channel 4 on Monday.
The broadcaster insisted the scene was not likely to encourage anyone to be violent.
A spokesman said: “Year of the Rabbit is a purposefully outrageous and heightened comedy set in Victorian era London featuring exaggerated and ridiculous fictional characters.”
The spokesman said it was “clear to viewers” that the characters “are preposterous and not to be taken seriously”.