Hatton – who was battling drug and alcohol problems – tried to kill himself in the years after his 10th round TKO loss to the American in 2007.
He also fell out with his parents Pat and Ray, and until six months ago was estranged from them.
But now the former light-welterweight and welterweight champ says he has healed the rift with the duo.
He told Manchester Evening News: “Ultimately when I fell out with my parents, I hit rock bottom.
“I didn’t care whether I lived or died to be honest with you.”
Later, he was exposed for allegedly taking cocaine and fell out with trainer Billy Graham.
“So if their parents are getting ill and passing away and all that, it’s not going to be long before mine go”
But he said he realised he had to resolve his conflicts following a number of his friend’s parent’s deaths.
He added: “A few of my school friends are the same age as me, their parents were having heart attacks and I was going to their funerals”
“And I thought to myself ‘I’m 40 now, I’m at an age where our parents might not be here much longer’.
“So if their parents are getting ill and passing away and all that, it’s not going to be long before mine go.
“I just made the effort to think ‘listen you know, let bygones be bygones, leave things in the past. That’s it’.”
And opening up about his loss to Mayweather, he continued: “I was always very depressed, even when I was a youngster. And then I had loads of success at boxing and then I didn’t. First time I had my defeat, it was very hard to come to terms with.
“I had a few personal problems as well, I fell out with my trainer, fell out with my mum and dad. Then I had a couple of wins so my confidence was back up, then I had another defeat and my confidence was back down”, he says.
“When the story came out in the newspaper (about him allegedly taking cocaine in a Manchester hotel), I was worried about public perception. I’ve always been the local lad, boy done well, kid next door. I was a very poorly man…I didn’t care where I was, what I was doing or who I was with.
“I fell out with my parents a few weeks earlier. So when that came in the papers, it was like a knock on effect.
“If I hadn’t fallen out with my mum and dad I don’t think I would’ve been as stupid to do that.
“I didn’t care whether I lived or died. So I wasn’t looking over my shoulder like I’d have done in years gone by.”
Last month, Hatton told Daily Star Online he suspected Manny Pacquiao may have been using performance enhancing drugs.